Glutathione Deficiency Can Cause Serious Health Conditions

The level of Glutathione in our cells is predictive of how long we will live. We need this miraculous antioxidant to survive, and without it, our liver would soon become overwhelmed with the accumulation of toxins, resulting in organ failure and death. Glutathione is manufactured by every one of our trillions of cells and is one of the most important healing and cleansing agents. Low glutathione levels are linked to diseases such as Cancer, Multiple Sclerosis, AIDS, Alzheimer’s, Parkinson’s, Atherosclerosis, pregnancy complications, male infertility and Cataracts. Glutathione is continuously defending our body against attacks from disease, toxins, poisons, viruses, pollutants, radiation and oxidative stress.

Every day our bodies are exposed to factors that drain our levels of glutathione: Stress, pollution, radiation, infection, drugs, poor diet, aging, injury and fatigue. These all contribute to glutathione depletion which, in turn, leads to cellular aging, disease and death. “Concern about maintaining one’s glutathione level will eventually be on par with other health maintenance issues.” says Dr. Bounous M.D.

Utilization of Glutathione GSH. Research has shown that individuals who have low levels of glutathione are susceptible to chronic illness. Research shows that GSH levels (glutathione) decline by 8% to 12% per decade, beginning at the age of 20. Levels of glutathione are further reduced by continual stress upon the immune system such as illness, infection, and environmental toxins. As we now know, a lowered immune system can bring about illness and disease. This is a ferocious cycle. While you need glutathione for a productive immune system, a weakened immune system hampers the production of glutathione. Supplements Containing Glutathione Alone Will NOT Increase The Body’s GSH Levels. It is pointless to purchase supplements that merely contain glutathione, because the digestive system breaks down ingested glutathione and it will not be absorbed into your system. On the other hand, Glutamine Prime provides the proper nutrients needed to promote the body's own ability to manufacture and absorb glutathione. Glutamine Prime also aids in liver support by destroying environmental poisons helping the liver to function as the main production site and storehouse for glutathione.

"It is well known that aging is accompanied by a precipitous fall in glutathione levels. Lower glutathione levels are implicated in many diseases associated with aging, including cataracts, Alzheimer's disease, Parkinson's, atherosclerosis and others." Journal of Clinical Epidemiology 47: 1021-26 1994"Low glutathione levels have been associated with neuro-degenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig's disease), Alzheimer's disease and Parkinson's disease, among others." The Lancet 344: 796-798, 1994

"Raised glutathione levels fight the oxidation of circulating fats in the bloodstream, including cholesterol, retarding the process of plaque formation in the arteries - the underlying cause for most heart disease and stroke". - Nutrition Reviews 54: 1-30, 1996

"Diabetics are prone to infections and circulatory problems leading to heart disease, kidney failure and blindness. Glutathione protects against the complications of diabetes"  - Clinical Science 91: 575-582, 1996

"Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. Newer potential therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses." - American Journal of Medical Science 307: 119-127, 1994

Dr. Earl Mindell - "We literally cannot survive without this miraculous antioxidant" Glutathione (GSH) : Your Body's Most Powerful Healing Agent

"Glutathione protects the body from the inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn's disease."  - Gut 42: 485-492, 1998

Dr. Jimmy Gutman, MD  - "Clinical evidence links low glutathione levels to the most common illnesses of our time as well as newly emerging diseases. Glutathione levels diminish as we age and many diseases normally associated with aging have been linked to glutathione deficiency." 

Ray Sahelian, M.D. - "L Glutathione is a powerful antioxidant found within every cell. Glutathione plays a role in nutrient metabolism, and regulation of cellular events (including gene expression, DNA and protein synthesis, cell growth, and immune response). 

The Roles of Glutathione GSH in People and Animals

Glutathione (GSH) is the body’s own health “AID to Energy”– Antioxidant, Immune Booster, Detoxifier and Energy enhancer. This small protein, produced naturally in the body, supports these four crucial functions. In fact, your life depends upon glutathione. Without it, your cells would disintegrate from unrestrained oxidation, your body would have little resistance to bacteria, viruses and cancer, and your liver would cease functioning from the accumulation of toxins. Medical science has described literally dozens of roles that glutathione plays in your body. However, the four most important roles of glutathione can be summarized by the acronym:

A I D = E2  These letters stand for:

    * Antioxidant
    * Immune support
    * Detoxifier
    * Energy

A –  “Your Master Antioxidant”
Over the past thirty years, advances in the study of antioxidants have grown to the point that a whole new branch of medicine has developed called “Free Radical Biology” which focuses on oxidant/antioxidant balance. Scientists have elaborated upon several hundred different disease processes where antioxidants play a vital role. The shelves of natural food stores and pharmacies are laden with a large array of different antioxidants offered. However, although these antioxidants, including vitamin C and vitamin E, are usually “natural”, they are not natural to your body. If you do not ingest these vitamins, they will not be found in your cells naturally. Given the importance of antioxidation in hundreds of different disease processes, one poses the question – “What antioxidant does the body manufacture to ward off these processes?” Glutathione is the most abundantly produced antioxidant in the body. In fact, the presence of this small protein is crucial for the functioning of all of the other known antioxidants, gaining the title “Master Antioxidant”.

I–  “Food for the Immune System”
Your immune system is constantly on the prowl for pathogens and foreign antigens—agents of cellular damage, toxicity and disease. These antigens include viruses, bacteria, parasites, fungi and even pre-cancerous cells. To neutralize these pathogens, the body needs a ready supply of glutathione. If it doesn’t have enough, some of the invaders will get through, infecting the body and/or contributing to aging, long-term accumulative damage—even eventual cancers. We can’t avoid illness and aging altogether, but by keeping our intracellular glutathione levels elevated, we also keep our immune system on full alert and fully armed. 

D–  “Detoxification System”
Hundreds of toxins are eliminated by the GSH enzyme system, including drug breakdown products, pollutants, carcinogens and radiation damage. It’s no surprise that GSH concentrations are highest in the liver, the body’s major detoxifying organ. We inhale and ingest natural and synthetic toxins every day of our lives and can’t possibly avoid them, especially in our technological era with congested and polluted cities and bio-engineered food supplies. Experimental studies have shown that low glutathione levels lead to poor liver and kidney function, and result in unnecessarily large quantities of toxins circulating through the body. There, they continuously damage individual cells and organs. The list of toxins eliminated include cigarette smoke, automobile exhaust and heavy metals. Physicians regularly use drugs to elevate glutathione levels in critical illnesses like acetaminophen overdose and severe liver failure.

E2-   “Energize Yourself”
Our cells are like little machines, running 24 hours a day. Where does the energy to fuel this constant activity come from? The answer is quite complicated but science had identified tiny structures within our cells called “mitochondria” which serve as tiny batteries inside the cell. Like any source of fuel, inevitably burning and waste products are a result. The mitochondria literally burn up oxygen and as a result are prone to overload and damage and are limited in their ability to continue working unless these breakdown products like oxyradicals are removed. The major substance produced by the cell to keep these mitochondria “cool” and efficient is glutathione. This translates into more energy and more strength. Raising glutathione has become a focus for many studies from sports medicine to anti-aging for this reason.

What Causes Us to LOSE Glutathione (GSH)?

Every day our bodies are exposed to factors that drain our levels of glutathione: Stress, pollution, radiation, infection, drugs, poor diet, aging, injury and fatigue. These all contribute to glutathione depletion which, in turn, leads to cellular aging, disease and death. “Concern about maintaining one’s glutathione level will eventually be on par with other health maintenance issues.” says Dr. Bounous.

Glutathione Research

In the last twenty years the volume of research into GSH has grown immensely. A huge variety of theoretical papers, bench-top laboratory experiments, epidemiological studies, animal projects and—most importantly—clinical trials on humans, has linked glutathione to an extraordinary variety of illnesses. Skeptics might doubt the length of the list were it not for the strength and credibility of the research. Much of the research on glutathione and the immune system was pioneered by Dr. Gustavo Bounous and Dr. Wulf Dröge who combined, have published hundreds of medical articles. A significant number of these papers have served as the foundation for many other studies and clinical trials on glutathione and immunology.

Eating Glutathione Will NOT Raise Your Body’s Glutathione Level

It is vital to clarify one particular aspect of the glutathione story. When people find out about GSH, they want to go to their health store, buy some and “take” it. Although it can be purchased as a supplement, eating glutathione has negligible effects on your health. It is quickly broken down in your digestive tract and eliminated. GSH must be manufactured within your cells, which is exactly where it is found—in every cell of your body. The only way to accomplish this effectively is to give your body the building blocks (precursors) it needs to manufacture glutathione for itself.    

Ask the person who referred you to this website to tell you about the natural product that can assist your body raise the glutathione level.

Glutathione is a small protein produced naturally in every cell of our body. It is made up of three protein building blocks, called amino acids. These are cysteine, glyceine, & glutamic acid. Your body produces glutathione inside every cell of your body, or that cell would quickly die. The levels of glutathione produced naturally is enough to keep the body working optimally under 'normal' conditions. Increasing levels of environmental pollutants and prolonged exposure to stress are depleting your body’s stores of glutathione increasingly fast.

The liver uses glutathione to process; alcohol, caffeine, medications, nicotine as an example, to process such substances and remove them from the blood. It also helps in the filtering of alcohol and other toxic substances from the blood. It helps in the processing of drugs and medications absorbed through the digestive system,, enabling the body to use them effectively and ultimately dispose of them. Reduced glutathione plays a critical role in the cellular detoxification processes including the metabolism of peroxides, the conjugation with electrophils and the scavenging of the free radicals. The relevance of glutathione in ethanol metabolism consists mainly in compensating for alcohol-related oxidative stress. Glutathione acts as a detoxifying agent by combining with undesirable substances and ridding the body of them through urine and bile .

White blood cells are the body’s major defense system. They need glutathione in order to *function *properly. By raising the levels of GSH glutathione, the body's master's antioxidant, the body can produce more white blood cells Glutathione depletion will eventually exhaust any ability of the white blood cells to keep fighting, which means: You loose the battle.

"The liver is the major storehouse for glutathione. Glutathione is impaired in alcoholic hepatitis as well as in viral hepatitis A, B, and C. Raised glutathione levels restore liver function." - American Journal of Gasteroenterology 91: 2569-2573, 1996

"Glutathione detoxifies a variety of pollutants, carcinogens and poisons, including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer" . - Annual Reviews of Biochemistry 52: 711-760 1983

"Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge." Journal of Applied Physiology 87: 1381-1385, 1999

"Strong muscular activity, such as that experienced by athletes, generates oxyradicals [free radicals] leading to muscle fatigue and poorer performance. Glutathione neutralizes these radicals". - Sport Medicine 21: 213-238, 1996

"Lymphocytes, cells vital for your immune system, depend on glutathione for their proper function and replication." - IMMUNOLOGY 61: 503-508 1987

"Antioxidants are well documented and known to possess vital roles in health maintenance and disease prevention. Glutathione is your cell's own major antioxidant. Maintaining elevated glutathione levels aids the body's natural antioxidant function." - Biochemical Pharmacology 47: 2113-2123 1994

The Role of Glutathione in Aging and Cancer   ---  PubMed.gov 
"The incidence and mortality rates from most cancers increase exponentially with age. It is likely that this aging phenomenon is partially due to specific changes that occur in the host resulting in an increased susceptibility to neoplasia. Our hypothesis is that one such host factor is a deficiency in GSH [Note: GSH is the medical abbreviation for reduced glutathione], based on the importance of this compound in the detoxification of a wide variety of exogenous and endogenous carcinogens and free radicals, as well as in the maintenance of immune function."  Animal study on the effect of glutathione on oral carcinogenesis

Joan Amtoft-Nielsen, MD, PhD, DC  - "Most cancer patients suffer from nutritional deficiencies before diagnosis and even more so during the early conventional treatment of their disease, since chemotherapeutic agents affect levels of such nutrients as glutathione, vitamin B6, vitamin E and beta carotene.  Inappropriate foods consumed during the course of disease may linger in the body longer since they are improperly digested, absorbed and excreted.  The greater the body’s toxicity, the lower the functioning of the immune system." Dr. Nielsen was a Medical Advisor for The National Foundation for Alternative Medicine in Washington DC and currently serves on the Scientific Advisory Board of the Journal of Longevity, on the Advisory Board of the C.A.R.E.S. Foundation and on the Board of Governors for the South Carolina Naturopathic Physicians Organization. 

Glutathione in Cancer Biology and Therapy Critical Reviews in Clinical Laboratory Sciences, Volume 43, Issue 2 March 2006 , pages 143 - 181

High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years

"Earlier we found a high percentage of subnormal total glutathione (G(T)) levels in blood from elderly subjects and patients with chronic diseases. These findings suggested a hypothesis that high levels of G(T) in the blood occur in old persons who are in excellent physical and mental health. To this end, we recruited 87 white women who ranged in age from 60 to 103 years and reported that they felt healthy. Their health was verified with physical examinations, clinical chemistry profiles, psychosocial assessments, and blood G(T) determinations. This evaluation was performed in three waves over a 5-year period. The values were compared with those from representative individuals in this region and with normal national data. The results verified that these healthy subjects were in top physical and mental health. We also found that subjects of all ages had very high blood G(T) levels in waves I and II but only normal levels in wave III. These findings confirm that high blood G(T) concentrations and excellent physical and mental health are characteristics of long-lived women." Department of Biochemistry, University of Louisville, KY - NIH.gov

Surviving Terminal Cancer: Clinical Trials, Drug Cocktails, and Other Treatments Your Oncologist Won't Tell You About

Glutathione: Blood Sugar Level, Thyroid Health
Glutathione (GSH) is a tripeptide formed from glutamic acid, cysteine, and glycine. Combined with vitamin E and selenium, glutathione forms glutathione peroxidase (GPx) which is one of the key antioxidants that protects the body and is critical for protection of the thyroid gland from oxidation damage.

Glutathione in overweight patients with poorly controlled type 2 diabetes
Changes in hepatic glutathione metabolism in diabetes
The road to better health may begin with a healing crisis (Herxheimer Reaction)

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HIV/AIDS

When Therapies Fail: One AIDS Activist's Fight for Better Clinical Options   Article by Neenyah Ostrom (July 11, 1999)

Glutathione Helps AIDS Survival    Proceedings of the National Academy of Sciences (1997;94:1967-1972)

Antioxidants nutrients are important in slowing the progression to AIDS from HIV infection    Interview with Dr. Luc Montagnier

N-Acetylcysteine Boosts T-Cell Function in HIV-Infected Patients  By Eliza Bussey (Reuters Health)

CFS Radio Program March 28th, 1999 [pdf]   Roger G. Mazlen, M.D. Host, with Dr. Gustavo Bounous, Dr. Allen C. Somersall and John Molson

Glutathione in Cancer Biology and Therapy Critical Reviews in Clinical Laboratory Sciences, Volume 43, Issue 2 March 2006 , pages 143 - 181

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Metabolism and Functions of Glutathione (GSH)

The oxygen we breathe helps to burn sugar and fat inside our body cells to produce energy. But about 2% of the converted oxygen remains as highly reactive molecules that modify, disrupt and impair the stable structure within our body. These are called “free radicals.” If free radicals are not neutralized, cell membranes breakdown and DNA is damaged, resulting in a compromised immune system, disease and rapid aging. Many environmental and ingested agents spur free radical production – air pollution, pesticides, radiation, alcohol, sugar, cigarette smoke, illegal drugs and prescription medications. To combat the hostile effect of free radicals, our bodies use antioxidants (free radical scavengers) that extinguish the biochemical fire. Bruce Ames, Ph.D. at the University of California, Berkley, estimates that every single one of our cells suffers from 10,000 hits by free radicals daily.

Glutathione is used more than any other antioxidant in the body, and is the most abundant natural antioxidant that protects our vision, boosts the immune system, helps turn carbohydrates into energy and prevents the buildup of oxidized fats that contribute to heart disease. Glutathione supports us at the cellular level by protecting every cell of the body, but our levels decline dramatically with age. Our bodies are constantly replacing and repairing free-radical damaged cells, but the demands of the modern age have created high levels of free radicals with limited supplies of Glutathione to correct the damage. Without Glutathione, other antioxidants such as vitamins C and E cannot perform their functions adequately to protect the body against disease.

The brain consumes about 20% of the oxygen utilized by the body but constitutes only 2% of the body weight and is therefore particularly susceptible to free radical attacks. Glutathione acts to prevent and protect the brain from the damage of free radicals.Glutathione protects both the mother and the developing fetus from the damaging effects of free radicals, and minimizes the oxidative stress that occurs during labor and the birth process. The placenta contains a significant amount of glutathione to filter pollutants before they reach the baby.

In the last 75 years, clean and healthy food supplies have been replaced by sugar, processed food, chemicals, genetically altered fruit and vegetables, chemical and hormone laced dairy products, hormone and preservative laden meats, high saturated fats with sugar and thousands of medications. There are tens of thousands of confirmed toxic substances in our environment and as a result, obesity, heart disease, diabetes, allergies and mental health issues are rampant. By age 20 we are losing Glutathione at 8-12% per decade. But compromised health and excessive use of medications can deplete the body more rapidly. Some scientists estimate that a 30% reduction of Glutathione is enough for cellular dysfunction to set in.

The liver is our ultimate cleaner and has two critical functions: to process nutrients and eliminate toxins from the body. It does this by filtering the blood at about two quarts a minute.  Approximately 25% of all the blood in the body is filtered through the liver at any one time. Some glutathione is released directly by the liver into the bloodstream where it helps to maintain the strength of red blood cells while also protecting the white blood cells. Large quantities of Glutathione are found in the liver where a two-stage detoxification process takes place. Phase One begins the chemical conversion of harmful compounds that are mainly fat-soluble into intermediate forms.  But Phase Two is where the final transformation takes place to converts the intermediate toxins into water-soluble substances that can be excreted thru the bowel or kidneys. Only water-soluble substances can be excreted. If there is not enough Glutathione to generate the Phase two enzymes, toxins will build to dangerous levels in the liver. 

Unlike unnatural detoxification supplements, the use of Glutathione is a natural process that allows our body to perform its filtering capability organically and comfortably.  Many herbs that detoxify will also deplete – Glutathione inherently builds and nourishes. Glutathione is a critical element for good health, strong immune function, cancer prevention and the slowing of the aging process.  Basically, increasing Glutathione levels enhances life. 

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